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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-124
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB and normal retina tissue; human RB cell lines Y79 and SO-RB50
Methods qRT-PCR, transwell assay, luciferase reporter assay, Western blot
Expression pattern down-regulated
Functional description The ectopic expression of miR-124 in the RB cell lines (Y79 and SO-RB50) suppresses cell proliferation, migration and invasion, induced cell apoptosis in vitro. Furthermore, signal transducer and activator of transcription 3 (STAT3) was identified as a new target of miR-124.
PubMed ID 27498908
Year 2016
Title miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3.
Drug-related ncRNA NO

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