ncRNA name | hsa-miR-124 |
ncRNA Category | miRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | RB and normal retina tissue; human RB cell lines Y79 and SO-RB50 |
Methods | qRT-PCR, transwell assay, luciferase reporter assay, Western blot |
Expression pattern | down-regulated |
Functional description | The ectopic expression of miR-124 in the RB cell lines (Y79 and SO-RB50) suppresses cell proliferation, migration and invasion, induced cell apoptosis in vitro. Furthermore, signal transducer and activator of transcription 3 (STAT3) was identified as a new target of miR-124. |
PubMed ID | 27498908 |
Year | 2016 |
Title | miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3. |
Drug-related ncRNA | NO |
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